Vismodegib, an antagonist of hedgehog signaling, directly alters taste molecular signaling in taste buds
نویسندگان
چکیده
منابع مشابه
Vismodegib, an antagonist of hedgehog signaling, directly alters taste molecular signaling in taste buds
Vismodegib, a highly selective inhibitor of hedgehog (Hh) pathway, is an approved treatment for basal-cell carcinoma. Patients on treatment with vismodegib often report profound alterations in taste sensation. The cellular mechanisms underlying the alterations have not been studied. Sonic Hh (Shh) signaling is required for cell growth and differentiation. In taste buds, Shh is exclusively expre...
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ژورنال
عنوان ژورنال: Cancer Medicine
سال: 2014
ISSN: 2045-7634,2045-7634
DOI: 10.1002/cam4.350